Amanda Nunes can make history on Saturday night when she battles featherweight contender Felicia Spencer in the main event of UFC 250. With a victory, Nunes, who enters Saturday’s bout with a 19-4 record, will become just the second UFC double champion to defend both titles. Nunes is the first female fighter to tout two UFC belts, but she’ll need to bring her A-game if she wants to retain them atop the UFC 250 fight card.

Spencer boasts an impressive 8-1 record in her career and is coming off a first-round TKO in her last bout against Zarah Fairn. The main UFC 250 card starts at 10 p.m. ET. Nunes is a -575 favorite (risk $575 to win $100), while Spencer is a +425 underdog in the latest UFC 250 odds from William Hill. In the co-main event, Cody Garbrandt (-150) squares off against Raphael Assuncao (+125) in a bantamweight fight. Before making your UFC 250 picks, make sure you see what SportsLine MMA analyst Brandon Wise has to say. 

A CBS Sports editor specializing in MMA, Wise has been dissecting the sport for five years. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year. Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov’s destruction of Conor McGregor in 2018, Stipe Miocic’s upset of Daniel Cormier, Max Holloway’s downfall in 2019 and Justin Gaethje’s TKO victory over Tony Ferguson in May. 

Across UFC 247, UFC 248 and UFC 249, Wise went 11-4 with his main-card picks, returning healthy profits for anyone following them. He also called Burns’ big upset last Saturday over Woodley, who was a -175 favorite. Anyone who has consistently followed Wise is way up.

Now, with UFC 250 fast approaching, Wise carefully has studied every matchup on the main card, identified the best value in the UFC odds and released his MMA picks for each fight. He’s only sharing those UFC picks here. 

Amanda Nunes vs. Felicia Spencer preview

Wise knows Nunes, who is also the UFC women’s bantamweight champion, will be making the first defense of her featherweight crown since making quick work of Cris Cyborg for the belt in December 2018. That victory, a 51-second knockout, made her the first woman in UFC history to win two titles and hold both simultaneously. 

Nunes (19-4) is riding a 10-fight winning streak, the longest by a woman in UFC history and ninth-longest overall in the promotion, and can tie men’s welterweight champion Kamaru Usman for the eighth-longest by defeating Spencer. The 32-year-old Brazilian, who defended her bantamweight title with a unanimous decision over Germaine de Randamie in December, owns the UFC women’s records for most wins (12) and most title-fight victories (seven). 

Spencer (8-1) atoned for her lone professional loss the last time she stepped into the Octagon, registering a first-round TKO victory over Zarah Fairn on Feb. 29 after losing a unanimous decision to Cyborg last July. The 29-year-old Canadian is no stranger to titles, as she defeated Pam Sorenson for the vacant Invicta Fighting Championships belt in November 2018 before signing with the UFC four months later. You can see Wise’s Spencer vs. Nunes picks here.

Top UFC 250 predictions

We’ll share one of Wise’s UFC 250 main-card picks here: He is backing Neil Magny (-150) to defeat Anthony Rocco Martin (+125) in a welterweight bout. 

Magny (22-7) enters Saturday’s bout having won three of his last four fights after posting a unanimous-decision victory over Li Jingliang in May. The 32-year-old connected on 123 of 188 total strikes against Jingliang while securing four takedowns in his victory. Now, Magny will look to use his size and powerful striking ability to defeat Martin at UFC Las Vegas.

“Magny is huge for the welterweight division at 6-foot-3 and creates plenty of issues for his opponents with his length,” Wise told SportsLine. “Magny should be able to keep this on his feet and grind out another decision.”

How to make Nunes vs. Spencer picks

Wise also has strong picks for Nunes vs. Spencer and every other bout on the main UFC 250 fight card. He’s also backing a fighter who has a “better all-around game to get scorecards in his favor.” Get every pick for every fight on the UFC 250 main card at SportsLine.

Who wins Nunes vs. Spencer at UFC 250? And how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight on the main UFC 250 card, all from the accomplished expert who has been profitable for five straight years, and find out.

UFC 250 odds (via William Hill)

Amanda Nunes (-575) vs. Felicia Spencer (+425)
Cody Garbrandt (-150) vs. Raphael Assuncao (+125)
Aljamain Sterling (-125) vs. Cory Sandhagen (+105)
Neil Magny (-150) vs. Anthony Rocco Martin (+125)
Sean O’Malley (-440) vs. Eddie Wineland (+340)