TP Mazembe need to overcome a first leg deficit in Africa's biggest club competition, which also sees a host of former big shots fighting to re-emerge by reaching the last 16.
FIFA.com wraps up all the weekend action around Africa, where leaders ESCOM United are taking it to the wire in Malawi and Asante Kotoko opened up a four-point lead in Ghana.
There were dramatic top of the table clashes in South Africa and Ghana, and the chasing teams made up ground in both cases as FIFA.com looks across the action in Africa this weekend.
Raja Casablanca scored late to salvage a draw in Morocco's Botola but fell from top spot, while leaders Dolphin FC claimed an eighth win from nine in Nigeria.
Trophies were clinched in Brazil and Malawi as the action began in Korea Republic, while the leaders fell from first place in Argentina and New Zealand.
Trophies will be raised in Brazil and Malawi as the season begins in Korea Republic, while the battles for glory continue apace in Argentina and Mexico.